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) is a city in Macon County, Alabama, United States. At the 2010 census the population was 9,865, down from 11,846 in 2000.

It was founded and laid out in 1833 by General Thomas Simpson Woodward, a Creek War veteran under Andrew Jackson, and made the county seat that year. Tuskegee has been an important site in African-American history and highly influential in United States history since the 19th century.

In 1923, the Tuskegee Veterans Administration Medical Center was established here, initially for the estimated 300,000 African-American veterans of World War I in the South, when public facilities were racially segregated.

Twenty-seven buildings were constructed on the 464-acre campus.

Beginning in 1932, the school was the site of the now-infamous Tuskegee syphilis experiment (1932–1972), started to test treatments of the disease.

With funding cut by the Great Depression, the Institute staff cut back on medications to treat the disease and studied the effects of untreated syphilis on patients and their partners.

The group and potential voters were often met with obstacles that prevented them from being successful.

Washington believed that African Americans would achieve acceptance by southern whites when they had raised themselves.

Washington led the school for decades, building a wide national network of white industrialist donors among some of the major philanthropists of the era, including George Eastman.

During World War II, Tuskegee and Tuskegee Institute were also home to the famed Tuskegee Airmen. The university in the 21st century is a center of excellence for African-American education.

This was the first squadron of African-American pilots trained in the U. The heart of the university has been designated as a National Historic District and was listed on the National Register of Historic Places in 1974.

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